Four inflammatory pathways addressed at once, not one. In controlled trials, curcumin performed comparably to diclofenac and ibuprofen, with fewer GI side effects. Manufacturer-endorsed standing pair with Total CMO.
Total FLM addresses four separate inflammatory pathways at once through boswellia, curcumin, ginger and quercetin. In controlled trials, curcumin performed comparably to diclofenac and to ibuprofen, with fewer GI side effects. The manufacturer states a standing pairing with Total CMO directly on the label.
Systemic inflammation without a single joint focus doesn't run through one mechanism. A formula built around a single anti-inflammatory route addresses part of the picture. This one addresses four separately.
5-LOX via boswellia. NF-kB and COX-2 via curcumin. The NLRP3 inflammasome and mast cells via quercetin — a distinct innate immune activation pathway from the other three. Both COX and LOX via ginger, complementing rather than duplicating boswellia and curcumin.
Boswellia and curcumin both carry real trial evidence in osteoarthritis, comparable to standard drug comparators in head-to-head trials — not comparisons against placebo alone.
A 2019 randomized controlled trial of 139 patients found curcumin, dosed at 500mg three times daily, performed comparably to diclofenac, with fewer adverse effects. A separate trial by Kuptniratsaikul found 2000mg of curcumin daily comparable to 800mg of ibuprofen. Sengupta's 2008 trial of 75 knee osteoarthritis patients used a 30% AKBA boswellia extract over 90 days and found dose-dependent improvement.
Those are direct, controlled comparisons against real drugs a patient may already be taking — not a vague "natural anti-inflammatory" claim. Reducing NSAID reliance is a legitimate goal here, coordinated with a physician rather than an unsupervised substitution.
| Component | Role |
|---|---|
| Indian Frankincense (Boswellia serrata, resin) | Boswellic acids inhibit 5-lipoxygenase, separate from cyclooxygenase. Sengupta 2008: 75 knee OA patients, 30% AKBA extract, 90 days, dose-dependent improvement. |
| Turmeric (curcumin, rhizome extract) | Acts on NF-kB and COX-2. 2019 RCT, 139 patients: curcumin 500mg 3x daily comparable to diclofenac, fewer adverse effects. Kuptniratsaikul: 2000mg daily comparable to ibuprofen 800mg. |
| Ginger (root) | Gingerols and shogaols act on both COX and LOX pathways, complementing rather than duplicating boswellia and curcumin. |
| Quercetin (plant) | Stabilizes mast cells and acts on the NLRP3 inflammasome, a distinct innate immune activation pathway from the other three mechanisms here. Undisclosed amount — see the full-disclosure note below. |
| Milk Thistle (seed and extract) | Both whole seed and standardized extract present. Silymarin supports hepatic antioxidant capacity. |
| Glutathione (reduced) | The body's master antioxidant, supplied directly rather than only supporting its own production. |
| Alpha Lipoic Acid | Regenerates glutathione, vitamin C and vitamin E after they're spent. The manufacturer's current label states 50% R form and 50% S form — the standard racemic mix, not the more expensive R-only isolate some formulas use. |
| Lemon Bioflavonoid (fruit) | Vascular and capillary support, a traditional companion to vitamin C and antioxidant work. |
| Cayenne (fruit) | Capsaicin depletes substance P at sensory nerve endings via TRPV1, and traditionally carries and directs the other actives. |
184mg proprietary blend, 10 components, individual amounts undisclosed. Vegetarian, gluten free.
Joint pain and stiffness, activity-related — boswellia and curcumin both carry real trial evidence in osteoarthritis, comparable to standard drug comparators.
Systemic inflammation without a single joint focus — the four-pathway coverage is the reason to reach for this over a single-mechanism formula.
Inflammation with an oxidative or hepatic component — reduced glutathione and alpha lipoic acid supplied directly, alongside milk thistle for hepatoprotection.
Wanting to reduce NSAID reliance — curcumin performed comparably to diclofenac and to ibuprofen in controlled trials, with fewer GI side effects.
Alongside Total CMO — a manufacturer-stated pairing. Different mechanism: immune signal versus the inflammatory cascade addressed here.
Because the joints and organs this formula supports have specific segmental supply. Brachial plexus, C5 to T1, reaches the shoulder, elbow, wrist and hand joints. Lumbosacral, L4 to S2, reaches the hip, knee, ankle and foot joints, along the sciatic and tibial distribution. The liver, via greater splanchnic from T5 to T9, is where milk thistle, glutathione and alpha lipoic acid all act, and where the body clears much of what systemic inflammation generates. Stomach and duodenum, T6 to T10, is where curcumin and ginger both act on GI mucosa directly. Gut-associated lymphoid tissue via lesser splanchnic, T9 to T12, is the largest immune organ in the body — relevant to the NLRP3 and mast cell mechanisms this formula addresses biochemically.
Supplementation addresses the inflammatory chemistry. Restoring normal segmental motion at each of these levels addresses the nervous-system signaling and local circulation governing how well the body uses it.
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It's a claim worth checking rather than accepting on faith, so here is exactly what the trial measured. A 2019 randomized controlled trial enrolled 139 patients and compared curcumin, dosed at 500mg three times daily, directly against diclofenac — a real prescription NSAID, not a placebo. The curcumin group performed comparably on the outcomes measured, with fewer adverse effects. A separate trial by Kuptniratsaikul found 2000mg of curcumin daily comparable to 800mg of ibuprofen. These are controlled, published, head-to-head comparisons against real drugs.
What this page won't do is imply that means switch off your NSAID and start this instead. This formula's own individual amounts of quercetin, boswellia, and the rest are undisclosed within the 184mg blend, and Total FLM has not itself been tested head-to-head against an NSAID as a whole product — the diclofenac and ibuprofen comparisons are for curcumin specifically, one ingredient among ten. The honest claim is narrower and more useful than a blanket substitution: curcumin has real evidence at a meaningful dose, and this formula includes it alongside three other genuinely different anti-inflammatory mechanisms.
Because that work isn't finished yet, and this page won't pretend otherwise. Dr. Frazier's tiered dosing protocol for this specific formula is still being confirmed. Until that's finalized, this page states the manufacturer's own label dose rather than presenting draft numbers as settled clinical guidance.
Testimonials reflect individual experiences and are not a guarantee of any clinical outcome.
| Each Tablet Contains | Amount |
|---|---|
| Proprietary blend — Indian Frankincense (boswellia), Milk Thistle (seed and extract), Turmeric (curcumin), Ginger, Lemon Bioflavonoid, Quercetin, Glutathione (reduced), Cayenne, Alpha Lipoic Acid | 184 mg |
Individual amounts are not disclosed within this blend, including quercetin. If you're on this formula without a full response, Quercetin-S supplies a known 200mg dose on top of this formula's undisclosed contribution.
Alpha lipoic acid form: the manufacturer's current label states 50% R form and 50% S form — standard racemic mix.
Other ingredients: dicalcium phosphate, microcrystalline cellulose, vegetable stearine, vegetable magnesium stearate, vegetable stearic acid. Vegetarian, gluten free, no declared allergens.
Suggested use: 1 tablet daily, or as directed — the manufacturer's label dose. Take with food; curcumin and the fat-soluble components absorb better alongside a meal containing fat. Absolute Health's tiered clinical dosing protocol for this specific formula is still being confirmed and will be added once finalized — this page states the label dose rather than presenting draft tiers as settled guidance.
Cautions: ginger, quercetin and curcumin all carry documented antiplatelet activity individually, and this formula combines all three — anyone on anticoagulant or antiplatelet therapy needs their prescriber informed before starting, and this is reasonably stopped two weeks before any scheduled surgical or dental procedure. Curcumin stimulates bile flow; caution in biliary obstruction or an active gallbladder attack. Alpha lipoic acid improves insulin sensitivity and stacks with glucose-lowering medication, and has been reported to affect thyroid hormone conversion — recheck rather than assume. Milk thistle carries theoretical estrogenic activity, worth physician input in hormone-sensitive conditions. Cayenne can irritate an already inflamed gastric lining or worsen reflux — take with food. No contraindication is declared in pregnancy or nursing, but physician direction remains the appropriate default.
| Product | Dose | Why |
|---|---|---|
| Total CMO manufacturer-stated pairing | 1 daily or as directed | Printed on the label itself. Total CMO addresses the immune signal underneath; this addresses the inflammatory cascade. Not vegetarian. |
| Total JT Plus or Complete FM | Per protocol | Where structural cartilage rebuilding is also needed alongside the inflammatory work here. |
| Complete A-G | 1 daily to 2 twice daily | Overlaps on alpha lipoic acid. Both products' current labels state the 50/50 R and S form, though Complete A-G's own clinical reference disputes that disclosure against a physical bottle check — know the overlap before stacking either way. |
| NAC Renew or Complete Glutathione | Per protocol | Overlaps on glutathione. This formula already supplies it directly; stacking with a precursor product is reasonable and deliberate rather than redundant. |
| Disc-Zym | Per protocol | A frequent pairing per that product's own reference. Disc-Zym supports absorption of what this formula and a structural protocol both depend on. |
| Complete MG | 1 AM and 1 PM to 2 and 2 | Magnesium supports smooth muscle and general inflammatory tone. Not in kidney failure or myasthenia gravis. |
| Complete Paleo | 1 scoop daily to booster | Collagen substrate for connective tissue rebuilding alongside the inflammatory control here. Not vegetarian. |
Products not yet linked will become live pages as they clear the clinical and schema review gate.
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Not every practice works at this level, and there is no fault in that — it is a different training. Ask these on the phone before you pay for a visit. If the answers are no, you have saved yourself an appointment.
If your provider referred you here, take the dossier to them — it is built to make that visit better. If you don’t have a provider working in this lane, Dr. Troy Delane Frazier, DC sees patients by telehealth and this is exactly the conversation he has been having since 1998.
Call to Schedule · (801) 221-1151Telehealth availability varies by state. Absolute Health, Orem, Utah.
The evidence is real and specific, though this page won't overstate it. In a 2019 randomized controlled trial of 139 patients, curcumin dosed at 500mg three times daily performed comparably to diclofenac, with fewer adverse effects. A separate trial by Kuptniratsaikul found 2000mg of curcumin daily comparable to 800mg of ibuprofen. Those are direct, controlled comparisons against real prescription and over-the-counter drugs — not a vague 'natural anti-inflammatory' claim. Anyone looking to reduce NSAID reliance has a specific reason to consider this, coordinated with their physician rather than as an unsupervised swap.
Because systemic inflammation isn't run through a single mechanism, and a formula built around one pathway only addresses part of the picture. This formula works four separately: boswellia inhibits 5-lipoxygenase, curcumin acts on NF-kB and COX-2, ginger works both COX and LOX pathways at once, and quercetin addresses the NLRP3 inflammasome and mast cell activation — a distinct innate immune pathway from the other three. For a patient with systemic inflammation rather than a single joint complaint, that four-pathway coverage is the actual differentiator.
Because it's a stated manufacturer pairing printed on the product record itself, not a clinical inference. Total CMO addresses the immune signal underneath joint inflammation through cetyl myristoleate; Total FLM addresses the inflammatory cascade directly through four separate pathways. Different mechanisms working the same presentation from different directions.
The same compound, but at an undisclosed amount here — this formula's 184mg blend doesn't break out how much of that is quercetin specifically. If you're on Total FLM without a full response, adding Quercetin-S supplies a known 200mg on top of this formula's undisclosed contribution, which is a deliberate escalation rather than redundancy.
Yes — the manufacturer's current label states 50% R form and 50% S form. This is the racemic mix most alpha lipoic acid supplements use, distinct from the more expensive R-only form some formulas isolate specifically.
Yes, and they're worth taking seriously rather than treating as boilerplate. Ginger, quercetin, and curcumin all carry documented antiplatelet activity individually, and this formula combines all three. Anyone on anticoagulant or antiplatelet therapy needs their prescriber informed before starting. Given that combined bleeding picture, this is reasonably stopped in the two weeks before any scheduled surgical or dental procedure, coordinated with the surgeon — not a decision to make alone the week of a procedure.
No. Total FLM is dispensed by Dr. Troy Delane Frazier, DC at Absolute Health, 560 South State Street, Suite H-1, Orem, Utah 84058, and ships nationwide. If your own provider referred you, enter their Referring Provider ID at checkout so the order is credited to them. Questions: (801) 221-1151.
180 tablets · four-pathway anti-inflammatory formula
Vegetarian · Gluten free · Ships nationwide
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