Six nutrients aimed at mitochondrial energy production — the compartment that declines with age. Three landmark PNAS papers, real human nerve-pain trials, and an honest reading of a mixed long-term result.
Fatigue that doesn’t answer to rest is frequently an energy-production question rather than a sleep question. Complete A-G supplies six nutrients — carnitine, lipoic acid, ornithine ketoglutarate, CoQ10, phosphatidylserine, and activated B6 — aimed at the mitochondrial changes that come with age.
You climb a flight of stairs you used to take without thinking, and you're aware of it. You read the same paragraph twice. Recovery from a hard day takes two days instead of one. The word most people reach for is aging, and once they reach for it, the conversation usually ends there.
Underneath that word is something specific. Inside almost every cell are mitochondria, which take the food you eat and the oxygen you breathe and turn them into ATP — the molecule your body spends to do anything at all. A heart muscle cell can hold thousands of them. A cell that works hardest has the most.
Mitochondria are also the largest producers of free radicals in the entire cell, because handling oxygen at that volume is inherently messy. Over decades, that oxidative traffic damages the mitochondria themselves: membrane potential falls, a key structural lipid called cardiolipin declines, enzymes lose their grip on the substrates they're supposed to bind, and carnitine — the molecule that carries fat into the mitochondria to be burned — becomes limiting. That's not a poetic description of getting older. It's a set of measurable, named changes.
Three separate papers were published side by side in the Proceedings of the National Academy of Sciences on February 19, 2002 — genuinely remarkable research, and largely unknown outside specialist circles.
Feeding old rats acetyl-L-carnitine and lipoic acid together partially reversed the age-related decline in mitochondrial membrane potential, significantly increased cellular oxygen consumption, and increased ambulatory activity — with the improvement significantly greater in old animals than in young ones. A companion paper found the pairing restored the binding affinity of a key fuel-utilization enzyme toward young-animal values. A third found partial reversal of memory loss on the Morris water maze, alongside reduced brain mitochondrial decay and reduced RNA and DNA oxidation. Old rats fed two nutrients for a month got up and moved like young ones. That work was published more than twenty years ago, and most people have still never heard of it.
Not across the board, and this page states the honest complication rather than only the positive result.
The strongest human evidence in this formula belongs to lipoic acid in nerve pain. The SYDNEY 2 trial randomized 181 patients to oral lipoic acid at 600, 1200, or 1800mg or placebo for five weeks; neuropathic symptoms and deficits improved, and 600mg daily was identified as the best balance of benefit to risk. A meta-analysis pooling four trials and 1,258 patients found intravenous lipoic acid safe and clinically meaningful.
The complication comes from NATHAN 1, a four-year trial of 460 patients on 600mg oral daily. Its composite primary endpoint — which bundled impairment scores together with seven nerve conduction tests — did not separate from placebo. The impairment scores themselves did, significantly. The reading that fits the data: the nutrient moved what patients and examiners could measure clinically without moving nerve conduction velocity, and both halves of that belong in the record.
The trials above tested one or two nutrients at a time, at doses chosen to isolate a single variable. That's the right design for proving a mechanism. It isn't how a mitochondrion actually works.
Energy production is a chain, not a step. Fat has to be carried in, which needs carnitine. Fuel has to enter the Krebs cycle, which needs lipoic acid as a cofactor for pyruvate dehydrogenase and gets a direct contribution from alpha-ketoglutarate. Electrons have to move down the respiratory chain, which needs CoQ10. The superoxide produced along the way has to be neutralized inside the compartment, which needs manganese superoxide dismutase. Membranes have to hold their structure, which needs phospholipids. And the enzymes running the whole thing need their cofactors, which is where B6 and biotin come in. A weak link anywhere on that chain limits everything downstream of it.
| Component | Role |
|---|---|
| Acetyl L-Carnitine | Carries long-chain fatty acids across the mitochondrial membrane to be burned. Becomes limiting with age. The acetylated form crosses into brain tissue and donates its acetyl group toward acetylcholine, the neurotransmitter of memory and attention. |
| Alpha Lipoic Acid | Both water and fat soluble — almost nothing else is. Enters the mitochondrion. Regenerates vitamin C, vitamin E, and glutathione after they've been spent. A cofactor for pyruvate dehydrogenase, feeding the Krebs cycle. Also activates the Nrf2 pathway, turning on the body's own antioxidant enzymes. |
| L-Ornithine (as ketoglutarate) | Serves two purposes: ornithine supports the urea cycle and ammonia clearance, while alpha-ketoglutarate is a Krebs cycle intermediate feeding directly into the energy pathway, and has drawn independent research attention in aging biology. |
| Co-Enzyme Q-10 | Carries electrons between complexes in the mitochondrial electron transport chain, the step immediately before ATP is made. Body production falls with age, and statin medications reduce it further. |
| Phosphatidyl Serine | A phospholipid concentrated in neuronal cell membranes, supporting membrane fluidity, receptor function, and signaling. One of the more studied nutrients in cognitive aging. |
| Pyridoxal-5-Phosphate | The already-activated form of vitamin B6, requiring no conversion by the liver. A cofactor in well over one hundred enzyme reactions, including every transamination step and most neurotransmitter production. Amount undisclosed. |
Plus biotin 33mcg, magnesium 10mg, and manganese 0.2mg — each disclosed, each a required cofactor for enzymes operating inside or alongside the mitochondrion.
Fatigue that does not answer to rest — the distinguishing feature. Sleep restores a sleep debt, not an energy production problem.
Mental fog, slower recall, harder concentration — neurons are among the most mitochondria-dense cells in the body and cannot be readily replaced.
Nerve pain, burning, tingling, or numbness — where the strongest human evidence in this formula lives. Long peripheral nerves depend on steady energy delivery down the entire axon.
Taking a statin medication — statins reduce CoQ10 production as a direct consequence of how they work.
Recovery from exertion taking longer than it used to — muscle recovery is an energy-dependent process.
Aging well as the goal, not fixing a specific complaint — the original research was aging research first.
Alongside neurological or nerve repair work — mitochondrial dysfunction sits underneath many nerve problems, which is why this pairs naturally with Complete Neuro and Complete Synapse rather than competing with them.
The label says one tablet daily — 241.5mg of the mitochondrial blend, 33mcg biotin, 10mg magnesium, 0.2mg manganese, at label amount. A higher tier, one to two tablets daily, delivers up to 483mg of the blend, above label and physician-directed. A full tier, two tablets twice daily, delivers up to 966mg of the blend alongside 132mcg biotin, 40mg magnesium, and 0.8mg manganese — well above label, physician-directed and monitored.
Take with food, and earlier in the day rather than late — the blend carries CoQ10 and acetyl-L-carnitine, both of which support energy production and are better placed earlier. Give it real time: the animal feeding studies ran weeks, and the human nerve trials ran five weeks at minimum, four years at the long end. Judging this at ten days is judging it before it has begun.
Mitochondria need three things delivered continuously: oxygen, fuel, and a working nerve supply to the tissue they sit in. The first two arrive through blood flow, and blood flow to any tissue is regulated by autonomic outflow organized segmentally along the spine. When a spinal segment loses normal motion, the altered afferent traffic shifts the sympathetic control of the small vessels perfusing that region — sustained vasoconstriction means less oxygen delivered to the mitochondria there, and mitochondria without oxygen cannot use the nutrients you send them.
There's a second layer for nerve tissue specifically. A peripheral nerve depends on axonal transport, an energy-dependent process moving mitochondria down the length of the axon. Mechanical irritation or compression anywhere along that path interferes with transport directly. A chiropractic adjustment restoring segmental motion addresses both the perfusion and the mechanical environment at once. Nutrition supplies the raw material. The nervous system controls whether it arrives.
Two minutes on the conversion step a single marker cannot report. Narrated from Dr. Troy Delane Frazier’s own clinical writing on this formula — his reasoning, his words.
Narrated summary of Dr. Frazier’s clinical rationale. Nothing plays until you click — no tracking loads on page view.
A fair suspicion, since a lot of formulas attach the word "mitochondria" without the underlying nutrients actually being chosen around that idea. This one is a genuine exception, and the test is specific: every one of the six nutrients either becomes limiting with age, or protects the specific compartment that suffers most from age. Carnitine falls with age. CoQ10 falls with age. Glutathione falls, and lipoic acid regenerates it. Membrane phospholipids degrade, and phosphatidylserine is one. This isn't a general antioxidant formula that happens to mention mitochondria — it's built around a specific idea: supply the molecules that become scarce, in the compartment where the scarcity does the most damage.
The research backing that idea is unusually strong for a supplement formula: three papers in the Proceedings of the National Academy of Sciences, published the same day, on the exact pairing of two of these nutrients. That's a real, checkable, landmark finding — not a citation dressed up to look more substantial than it is.
Two sources disagree, and this page states both rather than picking the more convenient one. The current Nutri-West website states the ratio directly: 50% R form, 50% S form. Dr. Frazier's clinical reference states the opposite, and cites a physical bottle from a specific manufacturing lot, checked in April 2025, that did not carry that disclosure. Either the website was updated after that lot was produced, or there's a genuine inconsistency between the website copy and current physical labeling. Confirm against the current physical label before treating either figure as settled.
Testimonials reflect individual experiences and are not a guarantee of any clinical outcome.
| Each Tablet Contains | Amount |
|---|---|
| Biotin | 33 mcg (110% DV) |
| Magnesium (as chelate) | 10 mg (2% DV) |
| Manganese (as chelate) | 0.2 mg (8% DV) |
| Proprietary blend — Acetyl L-Carnitine, Alpha Lipoic Acid, L-Ornithine (ketoglutarate), Co-Enzyme Q-10, Phosphatidyl Serine, Pyridoxal-5-Phosphate | 241.5 mg |
Alpha lipoic acid form: the current manufacturer website states 50% R / 50% S form directly. Dr. Frazier's clinical reference, citing a physical bottle checked in April 2025, states the ratio is not disclosed on that label. Both are recorded here — confirm against the current physical label.
Other ingredients: microcrystalline cellulose, vegetable magnesium stearate, vegetable stearic acid, silicate. Vegetarian, gluten free, no declared allergens.
Suggested use: 1 tablet daily, or as directed. Absolute Health standard matches label; higher tier 1–2 tablets daily; full tier 2 tablets twice daily, both above label and physician-directed. Take with food, earlier in the day.
Cautions: CoQ10 has been reported to alter warfarin response in both directions — coordinate with a prescriber on anticoagulant or antiplatelet therapy. Alpha lipoic acid improves insulin sensitivity and can interact with diabetes medication, and has been reported to affect thyroid hormone conversion. Activated B6 here is undisclosed by amount and also appears undisclosed in Complete Synapse — track cumulative B6 if stacking. Carnitine can produce a harmless body odor via gut bacterial conversion. High-dose biotin can interfere with certain lab immunoassays; the amount here is modest, but worth mentioning before a blood draw if biotin comes from several sources.
Also worth knowing: lipoic acid is a sulfur-bearing compound; a small number of sulfur-sensitive people notice it. Anyone with a seizure disorder should have their neurologist involved, given carnitine's discussed relationship to seizure threshold. Physician direction appropriate in pregnancy and nursing.
| Product | Dose | Why |
|---|---|---|
| Complete MG | 1 AM and 1 PM up to 2 and 2 | ATP is only biologically active when bound to magnesium — the most mechanically necessary partner in the group. Not in kidney failure or myasthenia gravis. |
| Complete Neuro | 1 daily or as directed | Aimed at the toxic and oxidative side of nerve injury, where Complete A-G is aimed at the energy side. Ginkgo and garlic both carry bleeding considerations. |
| Complete Synapse | 1 daily or as directed | Aimed at synaptic communication. Contains DHEA, a hormone precursor rather than a botanical, which changes who it suits. Overlaps this formula on alpha-ketoglutaric acid and pyridoxal-5-phosphate. |
| Total FLM | 1 daily or as directed | The standing inflammation choice at Absolute Health. The lipoic acid here overlaps this formula directly. |
| Total Mitochondria with Co-Q-10 Plus | Per protocol | The other mitochondrial pairing in the line. Overlaps on CoQ10, so these are selected deliberately rather than stacked by default. Contains egg and soybean. |
| Complete Glutathione or NAC Renew | Per protocol | Lipoic acid regenerates glutathione rather than replacing it, so supplying it directly gives the recycling system something to work on. |
Products not yet linked will become live pages as they clear the clinical and schema review gate.
Four stages. Each one builds on what the last one found — you paste the AI’s answer back in and the next prompt is written around it. You end with a document you can take to a doctor. This is education, not diagnosis.
Before anything else — what is actually happening underneath the symptom. This stage translates what you feel into the biological systems involved.
Your prompt will appear here.
Now the specifics of your case, written against what stage one found.
Complete stage 01 to unlock
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A visual of your own picture — the pathway involved and where this formula enters it. Paste into an image-capable AI.
Complete stage 02 to unlock
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Everything above, assembled into a document you can actually read and understand — what may be happening underneath, how this formula applies to you, and the questions to ask before you book.
Complete stage 03 to unlock
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Not every practice works at this level, and there is no fault in that — it is a different training. Ask these on the phone before you pay for a visit. If the answers are no, you have saved yourself an appointment.
If your provider referred you here, take the dossier to them — it is built to make that visit better. If you don’t have a provider working in this lane, Dr. Troy Delane Frazier, DC sees patients by telehealth and this is exactly the conversation he has been having since 1998.
Call to Schedule · (801) 221-1151Telehealth availability varies by state. Absolute Health, Orem, Utah.
Sleep restores a sleep debt. It doesn't restore an energy-production problem, and the difference is usually obvious to the person living it. Inside almost every cell are mitochondria, which convert food and oxygen into ATP — the molecule the body spends to do anything at all. Mitochondria are also the largest producers of free radicals in the cell, and over decades that oxidative activity damages the mitochondria themselves: membrane potential falls, a structural lipid called cardiolipin declines, key enzymes lose their grip on their substrates, and carnitine — the molecule that carries fat into the mitochondria to be burned — becomes limiting. That's a measurable, named set of changes, not a vague description of aging.
Genuinely remarkable research, and largely unknown outside specialist circles. Three separate papers were published side by side in the Proceedings of the National Academy of Sciences on February 19, 2002. Feeding old rats both nutrients together partially reversed the age-related decline in mitochondrial membrane potential, significantly increased cellular oxygen consumption, and increased ambulatory activity — with the improvement significantly greater in old animals than young ones. A companion paper found the combination restored a key fuel-utilization enzyme's binding affinity toward young-animal values. A third found partial reversal of memory loss on a maze test, alongside reduced brain mitochondrial decay and reduced RNA and DNA oxidation. That's animal research, not a claim about human outcomes, but it's the mechanistic foundation this formula is built on.
The strongest evidence in this entire formula, and it's specific to nerve pain. The SYDNEY 2 trial randomized 181 patients to oral lipoic acid at 600, 1200, or 1800mg or placebo for five weeks; neuropathic symptoms and deficits improved, and 600mg daily was identified as the best balance of benefit to risk. A separate meta-analysis pooling four trials and 1,258 patients found intravenous lipoic acid safe and clinically meaningful. The honest complication: a four-year trial called NATHAN 1, with 460 patients on 600mg daily, found its composite primary endpoint — which bundled impairment scores with nerve conduction tests — did not separate from placebo, even though the impairment scores themselves did, significantly. Both halves of that result belong in the record; the nutrient appears to move what patients and examiners could measure clinically without moving nerve conduction velocity.
This needs a direct answer rather than a confident guess, because two sources disagree. The current manufacturer website states "(Lipoic Acid - 50% R form and 50% S form)" directly in the product description. Dr. Frazier's clinical reference states the opposite — that the label does not specify the ratio — and cites checking a physical bottle from a specific manufacturing lot in April 2025 that did not carry this disclosure. Both facts are recorded here rather than one being silently chosen: the website may have been updated since that physical lot was produced, or there may be a genuine inconsistency between the website copy and current physical labeling. Confirm against the current physical label before treating either figure as final.
Because energy production is a chain, not a single step, and the clinical trials that isolated one nutrient at a time were testing mechanism, not real-world use. Fat has to be carried into the mitochondrion, which needs carnitine. Fuel has to enter the Krebs cycle, which needs lipoic acid as a cofactor and gets a direct contribution from alpha-ketoglutarate. Electrons have to move down the respiratory chain, which needs CoQ10. The superoxide produced along the way has to be neutralized, which needs manganese superoxide dismutase. Membranes have to hold their structure, which needs phospholipids. A weak link anywhere on that chain limits everything downstream of it — six modest contributions across the whole sequence is a different strategy from one large push at a single point.
Several worth taking seriously, especially in combination with other formulas. CoQ10 has been reported to alter warfarin response in both directions — on starting and on stopping — so anyone on anticoagulant or antiplatelet therapy needs their prescriber fully informed, especially if also running Complete Neuro's ginkgo and garlic or Total FLM's curcumin, quercetin, and ginger. Alpha lipoic acid improves insulin sensitivity and can interact with diabetes medication, and has been reported to affect thyroid hormone conversion. The activated B6 here is undisclosed by amount, and it also appears undisclosed in Complete Synapse — chronic high B6 intake carries its own nerve risk, which is worth a running total if several formulas are stacked. Carnitine can produce a harmless but surprising body odor in some people, via gut bacterial conversion. Biotin at much higher doses than found here can interfere with certain lab tests, including some thyroid and cardiac assays — worth mentioning before any blood draw if biotin is coming from several sources at once.
No. Complete A-G is dispensed by Dr. Troy Delane Frazier, DC at Absolute Health, 560 South State Street, Suite H-1, Orem, Utah 84058, and ships nationwide. If your own provider referred you, enter their Referring Provider ID at checkout so the order is credited to them. Questions: (801) 221-1151.
60 tablets · six-nutrient mitochondrial support
Vegetarian · No declared allergens · Ships nationwide
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