Milk thistle, a genuine four-enzyme digestive complex, and a disclosed alpha lipoic acid ratio. Real evidence for drug-induced liver injury; honestly mixed for hepatitis C. Three allergens hide in ingredients that don’t announce them.
Milk thistle in both seed and extract form, a genuine four-enzyme digestive complex, and alpha lipoic acid at a disclosed 50/50 R and S ratio. Best fit is a sustained medication load, alcohol history, or a stack of other formulas processed hepatically. Contains egg, soy and fish — sourced from ingredients that don’t announce them.
The most-cited liver herb in supplements doesn't work the same way for every liver condition. Stated honestly, by application, rather than as one blanket claim.
| Application | What the Evidence Shows |
|---|---|
| Drug-induced liver injury prevention | Real, favorable. Meta-analysis of 5 randomized controlled trials, 1,198 patients: significant reduction in anti-tuberculosis drug injury at 4 weeks, measurable ALT, AST and ALP improvement, no increase in adverse events. |
| Hepatitis C | Genuinely mixed. A meta-analysis and the 2012 JAMA trial both found no significant benefit on viral load or ALT versus placebo. |
| NAFLD and NASH | Promising, with real methodological caveats. Aminotransferase improvement shown; histological data limited by sample size. |
The favorable evidence for drug-induced liver injury ran a defined four-week window in the source trials — reassess periodically rather than continuing indefinitely without checking labs where that's the clinical picture.
| Component | Role |
|---|---|
| Vitamin A from cod liver oil | Traditional source. The fish allergen in this formula. |
| Vitamin C, Vitamin E, Choline | Antioxidant regeneration network plus lipotropic methyl donor support. |
| Milk Thistle seed and extract, both present | Real evidence for drug-induced liver injury prevention; genuinely mixed for hepatitis C. |
| Alpha Lipoic Acid 50% R, 50% S, disclosed | A disclosed ratio on this label. Total FLM's current label states the identical split — both formulas are transparent here, neither is uniquely the reference. |
| Cellulase, Amylase, Lipase, Protease | A genuine four-enzyme digestive complex, functionally overlapping with Total Enzymes. |
| Garlic, Beet | Hepatoprotective and traditional liver and bile support. Garlic carries independent antiplatelet activity. |
| Calcium D-Glucarate | Inhibits beta-glucuronidase — the same mechanism as DIM Renew, supporting clearance of already-conjugated compounds. |
| Phosphatidylcholine from soy | Hepatocyte membrane phospholipid. The soybean allergen in this formula. |
| Liver bovine , DL-Methionine | Glandular therapy plus a lipotropic sulfur amino acid. The liver is the source of this formula's not-vegetarian status. |
| Black Currant Seed Oil GLA | Series-1 anti-inflammatory pathway, shared with Complete Omega 3 Essentials, Core Level Lung, and Core Level Kidney. |
438mg proprietary blend. Individual amounts undisclosed except where noted above.
Sustained medication load or alcohol history — the population the drug-induced liver injury evidence speaks to most directly.
Alongside an active anti-inflammatory or structural protocol — where several other formulas in a stack are each processed hepatically. A deliberate rather than incidental choice.
Digestive complaints alongside a liver-focused presentation — the four-enzyme complex here means genuine double duty rather than needing a separate enzyme product.
Elevated liver enzymes, mild, under physician monitoring — ALT, AST, ALP improvement is the most direct evidence base, always alongside proper medical evaluation.
The label says one tablet daily, and Dr. Frazier's standard tier matches it. A split dosing pattern, one tablet in the morning and one in the evening, runs above label under physician direction. A higher tier, up to three tablets daily, occurs but is rarely needed — physician-directed and monitored when it is used. Take with food, given the digestive enzyme and fat-soluble content.
Because the organs this formula supports have specific segmental supply. The liver itself, via greater splanchnic from T5 to T9, is the primary level for this formula — governing hepatic vascular tone and secretory function. Vagal outflow, C1 to C2, contributes to hepatic blood flow and bile secretion alongside the sympathetic pathway. Pancreas and duodenum, T6 to T10, are relevant to the digestive enzyme content here. Small intestine via lesser splanchnic, T9 to T12, governs absorption of the enzyme, lipotropic and mineral components in this blend.
Supplementation supplies the hepatic and enzymatic substrate. Restoring normal segmental motion at each of these levels addresses the nervous-system signaling governing blood flow and secretory function to the organs actually doing the clearing.
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A fair suspicion, because milk thistle genuinely is in a lot of products, and blanket claims about it are common. The honest answer depends entirely on which condition is being discussed, and this page won't collapse three different findings into one marketing sentence.
For drug-induced liver injury specifically — the population taking a sustained medication load — the evidence is real: a meta-analysis of 5 randomized controlled trials and nearly 1,200 patients found a significant, measurable improvement in liver enzymes with no increase in adverse events. For hepatitis C, the honest answer is different: a meta-analysis and a major 2012 JAMA trial both found no significant benefit over placebo. Same herb, same formula, two genuinely different verdicts depending on what it's being asked to do.
Because the ingredients doing real hepatic work here happen to be sourced from cod liver oil, soy lecithin, and an egg-associated vitamin A source — none of which is obvious from a product called "Total Liver D-Tox." This page states all three plainly rather than assuming the name did the warning for it.
Testimonials reflect individual experiences and are not a guarantee of any clinical outcome.
| Each Tablet Contains | Amount |
|---|---|
| Vitamin A (from cod liver oil) | 300 mcg |
| Vitamin C (as ascorbic acid) | 25 mg |
| Vitamin E (as d-alpha tocopherol succinate) | 6 mg |
| Thiamine (as hydrochloride) | 5 mg |
| Choline (as bitartrate) | 12 mg |
| Magnesium (as chelate) | 10 mg |
| Zinc (as chelate) | 0.5 mg |
| Selenium (as chelate) | 25 mcg |
| Manganese (as chelate) | 0.1 mg |
| Proprietary blend — Milk Thistle (seed and extract), Cellulase, Amylase, Lipase, Protease, Garlic, Beet, Calcium D-Glucarate, Phosphatidylcholine, Liver (bovine), Black Currant Seed Oil, DL-Methionine, Alpha Lipoic Acid (50% R, 50% S) | 438 mg |
Other ingredients: microcrystalline cellulose, silicate, vegetable stearine, vegetable magnesium stearate, vegetable stearic acid.
Contains egg, soybean, and fish (cod). Egg and fish trace to the cod liver oil vitamin A source; soybean traces to the phosphatidylcholine. All three are absolute exclusions for the corresponding allergy, not cautions to weigh. Also not vegetarian or vegan due to bovine liver tissue.
Suggested use: 1 tablet daily, or as directed. Absolute Health standard matches label; a split AM/PM dose runs above label under physician direction; up to 3 tablets daily occurs but is rarely needed, physician-directed and monitored. Take with food.
Cautions: garlic carries independent antiplatelet activity — coordinate with a prescriber on anticoagulant or antiplatelet therapy. Alpha lipoic acid improves insulin sensitivity and stacks with glucose-lowering medication, and has been reported to affect thyroid hormone conversion. Existing significant liver disease needs physician oversight; this is adjunctive support only.
Refer out: jaundice, dark urine, pale stool, unexplained abdominal pain, or persistently elevated liver enzymes warrant prompt medical evaluation.
| Product | Dose | Why |
|---|---|---|
| Total FLM | 1 daily or as directed | Total FLM's own reference names the liver directly as where its milk thistle, glutathione, and ALA act. A natural pairing. |
| Total CMO or Total JT Plus | Per protocol | Supports hepatic clearance underneath structural or immune-signal joint work. |
| DIM Renew | 1 daily | Shares the calcium D-glucarate mechanism. Deliberate overlap, or select one as primary. |
| Total Enzymes or Hypo-D | Per protocol | Overlaps on digestive enzyme function. |
| Complete Glutathione or NAC Renew | Per protocol | Complements the alpha lipoic acid regeneration network already present here. |
| C-1000-TR | 1 daily to 5 daily | A larger vitamin C contribution to the same antioxidant regeneration network protecting ALA and glutathione here. |
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Not every practice works at this level, and there is no fault in that — it is a different training. Ask these on the phone before you pay for a visit. If the answers are no, you have saved yourself an appointment.
If your provider referred you here, take the dossier to them — it is built to make that visit better. If you don’t have a provider working in this lane, Dr. Troy Delane Frazier, DC sees patients by telehealth and this is exactly the conversation he has been having since 1998.
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Depends specifically on what it's being asked to do, and this page states the difference plainly. For drug-induced liver injury prevention, the evidence is real and favorable — a meta-analysis of 5 randomized controlled trials and 1,198 patients found a significant reduction in anti-tuberculosis drug injury at 4 weeks, with measurable ALT, AST and ALP improvement and no increase in adverse events. For hepatitis C, the evidence is genuinely mixed: a meta-analysis and a 2012 JAMA trial both found no significant benefit on viral load or ALT compared to placebo. For NAFLD and NASH, the picture is promising but has real methodological caveats — aminotransferase improvement has been shown, but histological data is limited by small sample sizes. Three different applications, three different levels of confidence, stated honestly rather than lumped together as one blanket claim.
Because the ingredients doing real work here come from sources that aren't obvious from their function. Vitamin A is sourced from cod liver oil — the fish allergen. Phosphatidylcholine, which supports hepatocyte membrane structure, is soy-derived — the soybean allergen. And the manufacturer's own vitamin A sourcing carries an egg declaration as well. All three are absolute exclusions for anyone with the corresponding allergy, not cautions to weigh.
Someone with a sustained medication load or an alcohol history is the population the drug-induced liver injury evidence speaks to most directly. It's also a deliberate rather than incidental choice for anyone running several other formulas in a stack, since a number of those are processed hepatically and benefit from support underneath them. Digestive complaints alongside a liver-focused presentation get genuine double duty from the four-enzyme complex here, and mildly elevated liver enzymes under physician monitoring are the most direct evidence-matched presentation — always alongside proper medical evaluation, not instead of it.
Yes — 50% R form and 50% S form, stated directly on the manufacturer's label. One correction worth making here: this isn't the only formula in the line to disclose that ratio. Total FLM's own current label states the identical 50/50 split. Both formulas are equally transparent on this point; neither is the sole reference.
For some patients, yes. The four-enzyme complex — cellulase, amylase, lipase, and protease — functionally overlaps with Total Enzymes. If digestive support and liver support are both needed, this formula can cover both without necessarily adding a second product, though the choice depends on which need is primary and how much enzyme support the digestive picture actually requires.
A few worth taking seriously. Garlic carries independent antiplatelet activity — coordinate with a prescriber on anticoagulant or antiplatelet therapy. Alpha lipoic acid improves insulin sensitivity and stacks with glucose-lowering medication, and has been reported to affect thyroid hormone conversion. Existing significant liver disease needs physician oversight; this is adjunctive support only, never a substitute. Jaundice, dark urine, pale stool, unexplained abdominal pain, or persistently elevated liver enzymes all warrant prompt medical evaluation — refer out rather than continue nutritional support alone.
No. Total Liver D-Tox is dispensed by Dr. Troy Delane Frazier, DC at Absolute Health, 560 South State Street, Suite H-1, Orem, Utah 84058, and ships nationwide. If your own provider referred you, enter their Referring Provider ID at checkout so the order is credited to them. Questions: (801) 221-1151.
180 tablets · hepatic, enzyme and lipotropic support
Contains egg, soy & fish · Not vegetarian · Ships nationwide
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