Full pathway support — raw material through conversion — not iodine alone. Two numbers in this formula need a clinician’s eyes before the first tablet, and they are printed below rather than buried.
Normal thyroid labs rule out a great deal — anemia, low B12 and vitamin D, sleep disruption, chronic stress. What a single TSH cannot see is peripheral conversion: T4 becoming active T3, a step run by deiodinase enzymes that require selenium. Total Thyroid #2 supports the full pathway rather than iodine alone.
Iodine 1500 mcg per tablet. The adult RDA is 150 mcg and the tolerable upper limit is 1100 mcg. One tablet alone exceeds the upper limit. Two tablets reach 3000 mcg. This is a deliberate therapeutic amount, not a top-up. Iodine effects are bidirectional — excess can cause hypothyroidism through the Wolff-Chaikoff effect, or trigger hyperthyroidism through Jod-Basedow.
Selenium 200 mcg per tablet, the largest amount of any product in this series. Two tablets reaches the adult upper limit from this product alone. Track cumulative selenium across your whole protocol.
Known or suspected Hashimoto’s, elevated TPO antibodies, nodular goitre or a hyperthyroid history requires practitioner judgement and monitoring before use — autoimmune thyroid patients are more sensitive to iodine excess, and higher intake has been linked to increased TPO antibodies.
On thyroid medication: coordinate, do not improvise. Levothyroxine absorption is impaired by the calcium and minerals here — separate dosing by several hours, and expect that labs may require re-titration.
When you are exhausted and cold all the time but your thyroid labs are normal, that panel has ruled out a great deal — and left one step unexamined.
Start with what the standard answer gets right, because it gets a lot right. Exhaustion and cold intolerance with a normal thyroid panel very often come from somewhere else entirely — iron deficiency or anemia reducing oxygen delivery, low vitamin D or B12, unrecognised sleep apnea, sustained cortisol elevation, or depression presenting physically. A full iron panel with ferritin, plus vitamin D and B12, is a genuinely good first move and it should not be skipped in favour of anything on this page.
Now the part that tends to go unexamined. Thyroid hormone is produced mostly as T4, which is comparatively inactive. It becomes active as T3 in peripheral tissue, converted by deiodinase enzymes — and those enzymes require selenium to run.
TSH reports the pituitary's view of circulating hormone. It is a good marker and it answers a real question. What it does not report is how efficiently that peripheral conversion is running in tissue. Those are different questions, and a single marker answers only one of them.
Possibly, and here is a specific cause almost nobody raises with patients.
Biotin — the ingredient in nearly every hair, skin and nail supplement — can interfere with certain thyroid immunoassays and produce inaccurate values. If you take a biotin-containing supplement and your panel came back normal, the panel may not be reporting what you think it is.
Flag it before any thyroid panel and ask whether it should be stopped beforehand. It costs nothing to ask, and that single question has resolved more than one mystery.
No, and it would be dishonest to present it as one.
Conventional endocrinology holds that a TSH within reference range effectively excludes primary hypothyroidism, and that position rests on real evidence and decades of clinical experience. Others argue that reference ranges are population-derived rather than individual, that antibodies can appear before TSH shifts, and that conversion problems are not visible on a TSH alone. Serious clinicians hold both positions.
What is not in dispute: a fuller panel gives more information than a single marker, and asking for one is reasonable. Whether it is warranted in your case is a conversation with a physician, not a conclusion to reach from a product page.
| Component | Pathway step |
|---|---|
| L-Tyrosine third by weight | Step one — the backbone. Thyroid hormone is built on a tyrosine skeleton. It is also the catecholamine precursor, which is one reason thyroid and adrenal pictures present together so often. |
| Iodine 1500 mcg, plus Kelp | Step two — the raw material. See the caution above; this amount is deliberate and above the upper limit. |
| Selenium 200 mcg as selenomethionine | The conversion step. Deiodinase cofactor for T4 to T3 — the step a TSH cannot see. Largest amount in the product series. |
| Ashwagandha · Guggul · Coleus Forskohlii · Gotu Kola | Thyroid-supportive botanicals working across conversion and metabolic pathways. |
| Thymus · Spleen · Adrenal · Pituitary · Parotid (bovine) | Glandular support reaching upstream to pituitary signalling. This is why the formula is not vegetarian. |
| American Ginseng · Eleuthero | Adaptogenic support for the adrenal overlap the tyrosine content already implies. |
| Larch Arabinogalactan · Yellow Dock · Betaine HCl | Immune and digestive support. |
| Disclosed nutrients | Vitamin A 153 mcg, Vitamin C 50 mg, Thiamine 5 mg, Riboflavin 5 mg, Niacin 2 mg, B-6 5 mg, Folate as L-5-MTHF 100 mcg, B-12 as methylcobalamin 100 mcg, Choline 24 mg, Calcium 30 mg, Zinc 1.5 mg, Manganese 0.8 mg, Molybdenum 30 mcg. |
563 mg proprietary blend across 16 components. Base: vegetable stearine, microcrystalline cellulose, vegetable stearic acid, vegetable magnesium stearate.
Because tyrosine is both the thyroid hormone backbone and the catecholamine precursor. One amino acid, two systems drawing on it. That shared dependency is a large part of why the two present together so often, and why a patient worked up for thyroid symptoms alone can end up addressing half a picture.
Where the adrenal overlap is significant, Dr. Frazier's clinical reference directs the work there directly — DSF Formula or Core Level Adrenal, one in the morning, titrated, nothing after noon on either.
The label figure is one tablet daily. At Absolute Health the standard is one tablet in the morning — where most cases begin and remain. A higher morning tier of two tablets exists but doubles both the iodine and the selenium, reaching the selenium upper limit from this product alone.
There is no evening tier. Late dosing raises metabolic pace and disrupts settling and sleep. And take it at the same time every morning — as the clinical reference puts it, the body runs a clock, and a clock reset every few weeks never tells the right time.
A palpable thyroid nodule, rapid heart rate, unexplained weight change, or eye changes warrant medical evaluation rather than nutritional management. Autoimmune thyroid disease under active management needs the practitioner judgement described above before starting. Anyone on thyroid medication coordinates with the prescriber. Pregnancy and nursing: the manufacturer states these herbs and nutrients are not extensively studied in that context.
Because the axis has specific segmental supply. Hypothalamic and pituitary regulation — the signal that starts the whole axis, matching the pituitary glandular in this formula — routes through C1 to C2, with upper cervical and suboccipital input from C0 to C3 feeding autonomic control of that region. The gland itself sits at T1 to T4 via the superior and middle cervical ganglia. The adrenal, the overlapping axis this formula acknowledges directly, is supplied via greater splanchnic from T8 to T11.
Supplementation supplies the substrate. Restoring segmental motion addresses the autonomic input governing the region that runs the axis.
Two minutes on the conversion step a single marker cannot report. Narrated from Dr. Troy Delane Frazier’s own clinical writing on this formula — his reasoning, his words.
Narrated summary of Dr. Frazier’s clinical rationale. Nothing plays until you click — no tracking loads on page view.
Most product pages spend their energy convincing you the answer is yes. For this formula specifically, the honest answer is: possibly not, and it depends on things a website cannot know about you.
One tablet exceeds the adult tolerable upper limit for iodine. That is deliberate and therapeutic, not an error — but it means this is a different category of product from a multivitamin. If you have Hashimoto's, elevated TPO antibodies, a nodular goitre, or any hyperthyroid history, iodine at this level needs a clinician's judgement and monitoring. Not a checkout button.
If you are on levothyroxine, adding this may change your labs enough to require re-titration, and the minerals here impair its absorption if taken together.
That is why this page leads with the numbers instead of burying them in a footnote. A formula this specific should be entered deliberately.
Agreed, and worth saying plainly. Before anything here: a full iron panel with ferritin, vitamin D, B12, and an honest look at sleep. Those account for a very large share of exhausted-and-cold-with-normal-labs, they are cheap to check, and no supplement substitutes for finding one of them.
Your doctor may well be right. Conventional endocrinology's position — that TSH in range effectively excludes primary hypothyroidism — rests on real evidence. This page does not claim otherwise. It raises a narrower point: a fuller panel including free T3 and antibodies reports something a TSH alone does not, and asking for one is a reasonable request rather than a challenge.
Testimonials reflect individual experiences and are not a guarantee of any clinical outcome.
| Per Tablet | Amount |
|---|---|
| Iodine RDA 150 mcg · UL 1100 mcg | 1500 mcg |
| Selenium as selenomethionine | 200 mcg |
| Vitamin A · Vitamin C | 153 mcg · 50 mg |
| Thiamine · Riboflavin · Niacin · B-6 | 5 / 5 / 2 / 5 mg |
| Folate (L-5-MTHF) · B-12 (methylcobalamin) | 100 mcg · 100 mcg |
| Choline · Calcium · Zinc · Manganese · Molybdenum | 24 mg · 30 mg · 1.5 mg · 0.8 mg · 30 mcg |
| Proprietary blend — L-Tyrosine, Kelp, Ashwagandha, Guggul, Coleus Forskohlii, Gotu Kola, Thymus, Spleen, Adrenal, Pituitary and Parotid (bovine), American Ginseng, Eleuthero, Larch Arabinogalactan, Yellow Dock, Betaine HCl | 563 mg |
Not vegetarian or vegan — contains bovine thymus, spleen, adrenal, pituitary and parotid.
Suggested use: 1 tablet daily. Absolute Health standard is 1 tablet in the morning, at the same time each day. There is no evening tier — late dosing raises metabolic pace and disrupts sleep.
Before any thyroid panel: flag any biotin-containing supplement you take. Biotin can interfere with certain thyroid immunoassays and produce inaccurate values.
Cautions: Coordinate with the prescriber if you take thyroid medication — separate dosing from levothyroxine by several hours; labs may require re-titration. Autoimmune thyroid disease requires practitioner judgement before use and monitoring during. Reproductive-organ or pituitary-sensitive conditions are physician-directed given the pituitary glandular. Pregnancy and nursing: not extensively studied. Track cumulative iodine and selenium across your whole protocol.
Refer out: palpable thyroid nodule, rapid heart rate, unexplained weight change, or eye changes warrant medical evaluation rather than nutritional management.
Four stages. Each one builds on what the last one found — you paste the AI’s answer back in and the next prompt is written around it. You end with a document you can take to a doctor. This is education, not diagnosis.
Before anything else — what is actually happening underneath the symptom. This stage translates what you feel into the biological systems involved.
Your prompt will appear here.
Now the specifics of your case, written against what stage one found.
Complete stage 01 to unlock
Your prompt will appear here.
A visual of your own picture — the pathway involved and where this formula enters it. Paste into an image-capable AI.
Complete stage 02 to unlock
Your prompt will appear here.
Image generators garble dense text. Proof the rendered image before showing it to anyone.
Everything above, assembled into a document you can actually read and understand — what may be happening underneath, how this formula applies to you, and the questions to ask before you book.
Complete stage 03 to unlock
Your prompt will appear here.
Not every practice works at this level, and there is no fault in that — it is a different training. Ask these on the phone before you pay for a visit. If the answers are no, you have saved yourself an appointment.
If your provider referred you here, take the dossier to them — it is built to make that visit better. If you don’t have a provider working in this lane, Dr. Troy Delane Frazier, DC sees patients by telehealth and this is exactly the conversation he has been having since 1998.
Call to Schedule · (801) 221-1151Telehealth availability varies by state. Absolute Health, Orem, Utah.
A normal panel rules out a great deal, and it should not be dismissed — anemia and iron deficiency, low vitamin D or B12, sleep disruption, chronic stress and mood conditions all produce this exact picture and all deserve checking first. What a single TSH cannot see is the peripheral step. Thyroid hormone is produced mostly as T4, which is comparatively inactive, and has to be converted to T3 in peripheral tissue by deiodinase enzymes that require selenium. TSH reports the pituitary's view of circulating hormone. It does not report how well that conversion is running in tissue.
It is common enough that entire clinics have written about it. Fatigue has many causes unrelated to the thyroid, and those should be worked up. But there is also a testing question worth raising: TSH alone is a single window onto a multi-step system, and a fuller panel including free T4, free T3 and thyroid antibodies gives a different amount of information. Whether that broader panel is warranted in your case is a conversation for a physician, not a conclusion to reach from a product page.
This is a genuinely contested area and it deserves an honest answer rather than a confident one. Conventional endocrinology holds that TSH within reference range effectively excludes primary hypothyroidism, and that position rests on real evidence. Others argue that reference ranges are population-derived rather than individual, that antibodies can be present before TSH shifts, and that conversion problems are not visible on a TSH alone. Both positions have serious clinicians behind them. What is not contested: a full panel gives more information than a single marker, and asking for one is reasonable.
Here is one specific possibility almost nobody mentions, and it may apply directly to you. Biotin — the ingredient in most hair, skin and nail supplements — can interfere with certain thyroid immunoassays and produce inaccurate values. If you take a biotin-containing supplement, your panel may not be reporting what you think it is. Flag it before any thyroid panel and ask whether it should be stopped beforehand. That single question has resolved more than one mystery.
Because it is a deliberate therapeutic amount rather than a top-up, and you should know the numbers before the first tablet. One tablet supplies 1500 mcg of iodine. The adult RDA is 150 mcg and the tolerable upper limit is 1100 mcg — so a single tablet exceeds the upper limit, and two tablets reach 3000 mcg. Iodine effects are bidirectional: excess can cause hypothyroidism through the Wolff-Chaikoff effect, or trigger hyperthyroidism through Jod-Basedow. This is not a formula to self-escalate.
Then this requires practitioner judgement before starting, not routine dispensing. Hashimoto patients are more sensitive to iodine excess, and higher iodine intake has been linked to increased TPO antibodies. The same applies to known or suspected Hashimoto's, elevated TPO, nodular goitre, or any hyperthyroid history. It is not that the formula is automatically wrong in those cases — it is that the decision belongs to a clinician who can monitor, not to a checkout button.
Coordinate with the prescriber rather than improvising. Levothyroxine absorption is impaired by calcium and other minerals, and this formula contains both — so dosing needs separating by several hours. Adding it may also change your labs enough to require re-titration of your medication. This is not a substitute for titrated thyroid medication and should not be treated as one.
It is the largest selenium amount of any product in this series, and two tablets reaches the adult upper limit from this product alone. Selenium is there for a specific reason — it is the deiodinase cofactor that runs T4 to T3 conversion, the exact step a TSH cannot see. But it needs tracking cumulatively across your whole protocol, especially alongside any other thyroid formula, mineral supplement or multivitamin.
No. Total Thyroid #2 is dispensed by Dr. Troy Delane Frazier, DC at Absolute Health, 560 South State Street, Suite H-1, Orem, Utah 84058, and ships nationwide. Given the iodine and selenium amounts in this particular formula, a conversation before starting is worth having rather than optional. If your own provider referred you, enter their Referring Provider ID at checkout. Questions: (801) 221-1151.
90 tablets · full-pathway thyroid support with glandulars
Contains bovine glandulars · Not vegetarian · Practitioner-directed
Personalized product matches based on your goals