For the week that arrives on schedule and takes the month with it. Pituitary-acting support plus the cofactors the liver uses to clear estrogen — not a hormone, and not a symptom mask.
After ovulation estrogen falls and progesterone rises then falls, and those shifts move serotonin. The usual account stops there. It rarely asks whether the body is clearing those hormones efficiently. Total Female supplies chaste tree, which acts on the pituitary, plus the B vitamins the liver uses to process estrogen.
The standard answer is that hormones shift and the brain reacts. That is true. It is also only half of a two-sided process.
Here is the account you will find almost everywhere, and it is accurate. After ovulation, estrogen peaks and then drops. Progesterone rises and then falls if pregnancy does not occur. Those shifts affect serotonin, which governs mood, sleep and energy. Some brains react more strongly to those normal changes than others — which is how the medical literature describes the difference between PMS and PMDD.
Now notice the shape of that explanation. Hormones are described as being produced and then shifting. Nowhere in it does anyone ask what happens to those hormones next.
Estrogen is not only produced. It has to be processed and deactivated, and that work happens in the liver across two phases. Phase one modifies it. Phase two conjugates it for elimination. Both phases run on specific nutrients.
B6 supports hepatic estrogen processing — and separately serves as a cofactor for progesterone synthesis and for serotonin, dopamine and GABA. Methylated B12 drives estrogen deactivation. Riboflavin runs glutathione reductase, which is central to phase-two clearance. When that machinery runs slowly, the question is no longer only how much estrogen was made. It is how much is still circulating.
Dr. Frazier's clinical reference names sluggish hepatic clearance and estrogen dominance among the systemic presentations this formula is selected for — alongside the phrase that recurs across his work: symptoms on a normal panel.
Most approaches do one of two things: replace a hormone, or manage a symptom. Chaste tree does neither. It acts on the pituitary — the gland that signals the ovaries — which places it upstream of both.
It carries the strongest trial record of any botanical in this formula, and it appears twice in the ingredient panel. That is a deliberate formulation choice rather than an accident of listing.
| Component | Role |
|---|---|
| Chaste Tree (leaf, berry) strongest trial record | Pituitary-acting. Upstream signalling rather than hormone supply. Listed twice in the panel. |
| B6 3 mg · B12 100 mcg methylcobalamin | B6: hepatic estrogen processing, progesterone synthesis, and cofactor for serotonin, dopamine and GABA. B12 in methylated form drives estrogen deactivation. |
| Riboflavin 1.8 mg · Thiamine 1.5 mg · Niacin 5 mg | Riboflavin runs glutathione reductase for phase-two clearance. Niacin supplies NAD. |
| Vitamin A 300 mcg · Vitamin C 25 mg | Endometrial and epithelial integrity. The adrenal cortex holds the highest tissue concentration of vitamin C in the body. Vitamin A here is from cod liver oil — the reason this formula is not vegetarian. |
| Magnesium 20 mg · Zinc 5 mg · Selenium 20 mcg | Zinc participates in ovulation, progesterone production and thyroid conversion. Selenium runs the T4 to T3 deiodinase. Magnesium here is a supporting rather than therapeutic amount. |
| Black Cohosh · Dong Quai · Red Clover · Wild Yam · Red Raspberry · Motherwort · Damiana | Transition support, cycle comfort and uterine tone. Wild yam is antispasmodic. Motherwort is both cardiac and calming. |
| Asian Ginseng · Gotu Kola · Oat · DGL Licorice · Pregnenolone | Adrenal and nervous-system support. Licorice is deglycyrrhizinated, removing the blood-pressure concern. Pregnenolone is a hormone precursor, amount undisclosed. |
| Chlorella · Flaxseed · Burdock · Lemon Bioflavonoid · Pepsin, Lipase, Amylase · Boron | Clearance, binding and absorption support. Boron slows 24-hydroxylase, extending circulating vitamin D, estrogen and testosterone. |
Other ingredients: microcrystalline cellulose, vegetable stearine, vegetable magnesium stearate, vegetable stearic acid.
Cycle: irregular cycles, premenstrual irritability and mood change, breast fullness, cycle headache, dysmenorrhea, luteal phase insufficiency.
Transition: perimenopausal onset, hot flushes, night sweats, declining drive and energy, sleep disruption, and post-hysterectomy or oophorectomy support.
Systemic: symptoms on a normal panel, estrogen dominance, sluggish hepatic clearance, cortisol competing for precursor, and urinary tract and pelvic tissue support.
The label figure is one tablet daily. At Absolute Health the standard is one daily, with a higher tier of one tablet one to two times daily, a full tier of one tablet one to three times daily, and a concentrated option of two tablets in the morning.
Taken daily rather than cycle-timed, with food. Reassess at two to three cycles rather than at two to three weeks — the cycle is the unit of measurement here, and a single month is not enough signal to judge by. Tiers above one daily are physician-directed.
Intermenstrual or postmenopausal bleeding, and severe pelvic pain, warrant medical evaluation rather than nutritional support — those are refer-out situations in Dr. Frazier's clinical reference, not judgement calls.
And PMDD is not a supplement problem. It is a recognized psychiatric diagnosis with established treatments and elevated risk, and it deserves real care. Nutritional support may have a place alongside that care. It is not a substitute for it. If you are experiencing thoughts of self-harm, the 988 Suicide and Crisis Lifeline is available by call or text at any hour.
Because the relevant organs have specific segmental supply. Hypothalamic and pituitary regulation, along with vagal outflow, routes through C1 to C2 — matching the pituitary-acting botanical in this formula. Thyroid and parathyroid sit at T1 to T4. T7 to T9 supplies liver and gallbladder, which is where hormone clearance happens. T10 to T11 covers adrenal and ovary. T12 to L2 reaches uterus, upper vagina, kidney and ureter, and S2 to S4 the uterus, cervix, bladder and pelvic floor.
Supplementation supplies the cofactors. Restoring segmental motion addresses the signalling that governs how they get used.
Two minutes on the half of the hormone conversation that gets left out. Narrated from Dr. Troy Delane Frazier’s own clinical writing on this formula — his reasoning, his words.
Narrated summary of Dr. Frazier’s clinical rationale. Nothing plays until you click — no tracking loads on page view.
People search that question, and it deserves a straight answer rather than the one a supplement page would prefer to give.
PMDD is a recognized psychiatric diagnosis, not a wellness category. It involves intense depression, extreme anger, panic and disabling fatigue, and it carries elevated risk. It has established treatments with real evidence behind them. Anyone telling you a supplement cures it is selling you something, and the cost of believing them is measured in months of a life that is already hard.
If PMDD is what you are dealing with, see a physician. Nutritional support may have a place alongside that care. It is not a replacement for it, and this page will not pretend otherwise.
If you are having thoughts of self-harm, please reach out now — the 988 Suicide and Crisis Lifeline is available by call or text at any hour.
The larger group: cycle symptoms that are genuinely disruptive without meeting a diagnostic threshold. Irritability that shows up on schedule. Breast fullness, cycle headache, cramping. Irregular cycles. The perimenopausal transition. And the pattern Dr. Frazier names repeatedly across his work — symptoms with a normal panel, where a clearance question has never been asked.
Possibly, and for many patients those are the right answer. Neither one addresses the clearance side, which is not a criticism of them — it is simply a different question. Bring the label to your appointment and ask about both.
Testimonials reflect individual experiences and are not a guarantee of any clinical outcome.
| Per Tablet | Amount |
|---|---|
| Vitamin A (from cod liver oil) | 300 mcg |
| Vitamin C | 25 mg |
| Thiamine · Riboflavin · Niacin | 1.5 / 1.8 / 5 mg |
| Vitamin B-6 (pyridoxine HCl) | 3 mg |
| Vitamin B-12 (methylcobalamin) | 100 mcg |
| Magnesium (malate) · Zinc · Selenium | 20 mg / 5 mg / 20 mcg |
| Botanical and glandular blend — Chaste Tree (leaf, berry), Black Cohosh, Dong Quai, Red Clover, Wild Yam, Red Raspberry, Motherwort, Damiana, Asian Ginseng, Gotu Kola, Oat, DGL Licorice, Pregnenolone, Chlorella, Flaxseed, Burdock, Lemon Bioflavonoid, Pepsin, Lipase, Amylase, Boron | — |
Other ingredients: Microcrystalline cellulose, vegetable stearine, vegetable magnesium stearate, vegetable stearic acid.
Allergen — read this: contains Fish (cod). Not vegetarian. The vitamin A is cod-liver sourced.
Suggested use: 1 tablet daily with food, or as directed. Daily rather than cycle-timed. Reassess at 2 to 3 cycles. Tiers above 1 daily are physician-directed.
Cautions: Not appropriate in pregnancy. Hormone-sensitive cancer is physician-directed given the pregnenolone and red clover content. Dong quai, red clover and flaxseed carry anticoagulant considerations and chlorella contributes vitamin K — coordinate with your prescriber if you take a blood thinner. Black cohosh has hepatic case reports. Track cumulative B6 across your whole protocol: 9 mg at three tablets, and Glan-Plus-F adds 15 mg per tablet.
Refer out: intermenstrual or postmenopausal bleeding, or severe pelvic pain, warrant medical evaluation rather than nutritional support.
Four stages. Each one builds on what the last one found — you paste the AI’s answer back in and the next prompt is written around it. You end with a document you can take to a doctor. This is education, not diagnosis.
Before anything else — what is actually happening underneath the symptom. This stage translates what you feel into the biological systems involved.
Your prompt will appear here.
Now the specifics of your case, written against what stage one found.
Complete stage 01 to unlock
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A visual of your own picture — the pathway involved and where this formula enters it. Paste into an image-capable AI.
Complete stage 02 to unlock
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Everything above, assembled into a document you can actually read and understand — what may be happening underneath, how this formula applies to you, and the questions to ask before you book.
Complete stage 03 to unlock
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Not every practice works at this level, and there is no fault in that — it is a different training. Ask these on the phone before you pay for a visit. If the answers are no, you have saved yourself an appointment.
If your provider referred you here, take the dossier to them — it is built to make that visit better. If you don’t have a provider working in this lane, Dr. Troy Delane Frazier, DC sees patients by telehealth and this is exactly the conversation he has been having since 1998.
Call to Schedule · (801) 221-1151Telehealth availability varies by state. Absolute Health, Orem, Utah.
Anger and irritability in the luteal phase are among the most common complaints and among the least discussed, partly because they are harder to say out loud than fatigue or bloating. Estrogen influences serotonin, and serotonin governs mood regulation and impulse control. When estrogen falls after ovulation, that regulation gets harder. Dr. Frazier's clinical reference lists premenstrual irritability and mood change among the cycle presentations this formula is selected for. If the anger is severe, frightening, or damaging relationships, that is PMDD territory and needs a physician rather than a supplement.
Start by tracking it for two to three cycles, because the pattern itself is diagnostic — symptoms that appear after ovulation and lift within a few days of bleeding starting point at the cycle rather than at depression that happens to coexist with it. Sleep, protein intake, and blood sugar stability all move the needle and cost nothing. Nutritional support targets the substrate underneath: B6 is a cofactor for serotonin, dopamine and GABA synthesis, and it is also required for progesterone synthesis and hepatic estrogen processing. If the sadness is severe, persistent, or includes thoughts of self-harm, that needs care now — the 988 Suicide and Crisis Lifeline is available by call or text at any hour.
PMDD is diagnosed against formal criteria that include marked mood swings, irritability or anger, depressed mood or hopelessness, anxiety or tension, decreased interest in usual activities, difficulty concentrating, fatigue, appetite changes, sleep disturbance, a sense of being overwhelmed or out of control, and physical symptoms such as breast tenderness or bloating. The diagnostic threshold requires several of these, confirmed by prospective tracking across at least two cycles, with meaningful interference in daily life. That evaluation belongs with a physician. This page is not a substitute for it, and PMDD specifically is not a condition to self-manage with a supplement.
The defining feature is timing rather than duration. Luteal-phase mood symptoms typically begin after ovulation, intensify in the days before bleeding starts, and resolve within two to three days of the period beginning — with a symptom-free stretch afterward. That symptom-free window is what distinguishes a cycle-linked pattern from depression that is present throughout the month. If low mood never fully lifts, the cycle is not the whole story and a broader evaluation is warranted.
Considerably more severe than PMS, and the distinction matters clinically. PMDD involves intense depression, extreme anger, panic, and disabling fatigue that disrupt work and relationships — one description in a patient community called it a full emotional blackout. It is a recognized psychiatric diagnosis with established treatments including SSRIs and hormonal approaches, and it carries elevated risk that should not be managed alone. If this describes your experience, see a physician. Nutritional support may have a role alongside care; it is not a replacement for it.
Because it works upstream. Most approaches either supply a hormone or manage a symptom. Chaste tree acts on the pituitary — the gland that signals the ovaries — rather than supplying hormone itself, which is a different kind of intervention. Dr. Frazier's clinical reference notes it has the strongest trial record of any botanical in this formula, and it is listed twice in the ingredient panel.
More than almost any page on this subject mentions. Estrogen is not only produced — it has to be processed and deactivated, and that work happens in the liver across two phases. B6 supports hepatic estrogen processing. Methylated B12 drives estrogen deactivation. Riboflavin runs glutathione reductase, which is central to phase-two clearance. When that machinery runs slowly, the picture is not only how much estrogen is made but how much is still circulating. Dr. Frazier's clinical reference names sluggish hepatic clearance and estrogen dominance among the systemic presentations this formula addresses.
Yes, and two are easy to miss. This formula contains vitamin A from cod liver oil, so it contains fish and is not vegetarian — despite the general assumption that these formulas are allergen-free. Black cohosh has hepatic case reports associated with it. Dong quai, red clover and flaxseed carry anticoagulant considerations, and chlorella contributes vitamin K, so anyone on a blood thinner should coordinate with their prescriber. Pregnenolone and red clover make hormone-sensitive cancer a physician-directed decision. Not appropriate in pregnancy. And if you take Glan-Plus-F alongside this, track cumulative B6 — three tablets here supply 9 mg and Glan-Plus-F adds 15 mg per tablet.
No. Total Female is dispensed by Dr. Troy Delane Frazier, DC at Absolute Health, 560 South State Street, Suite H-1, Orem, Utah 84058, and ships nationwide. If your own provider referred you, enter their Referring Provider ID at checkout so the order is credited to them. Questions: (801) 221-1151.
90 tablets · hormone balance and urinary tract support
Contains fish (cod) · Not vegetarian · Ships nationwide